مقالات

Sequence analysis of mitochondrial DNA hypervariable regions: an approach to personal identification

Mitochondrial DNA (mtDNA) sequence analysis of the hypervariable control region has been shown to be an effective tool for personal identification. The high copy and maternal mode of inheritance make mtDNA analysis particularly useful when old samples or degradation of biological samples prohibits the detection of nuclear DNA analysis.
Plasmid DNA Production for Genetic Immunization in Fed-Batch Fermentation with Feed Back Controls Based on Dissolved Oxygen (DO) and pH

A fermentation process for production of super coiled plasmid DNA in E. coli for use as a DNA vaccine was developed. In the process a feed-back control nutrient feeding strategy based on pH and DO was used to regulate the cell growth rate by controlling the interactivity of the nutrient feed rate, pH and DO.